Archive for the ‘Anti-Inflammatory’ Category

Mangosteen: The Miracle Fruit?

Thursday, August 26th, 2010

“Learn to live with it.”

Mangosteen - Miracle Fruit
That’s what Mike’s doctor told him when he just couldn’t get rid of the chronic pain in his shoulders, a result of years playing professional baseball. He was also told that the prescription anti-inflammatory drugs he was on would eventually destroy his liver.

Mike quit the drugs immediately. But chronic inflammation flared up like a fire inside his body. To top it off, Mike battled severe acid reflux disease and persistent allergies. He felt 30 years older than the 60 years his birth certificate showed.

Inflammation’s Double-Edge Sword

Inflammation is our body’s natural response to injury and infection. It’s a necessary process for protecting and repairing our bodies. However, chronic inflammation like Mike’s can significantly and adversely affect our body’s cells. It’s been directly linked to heart attacks, stroke, and Alzheimer’s – and suspected in many other disease processes. It’s also a tremendous source of pain.

For Mike, the “heat” was on to find relief. At first, his doctor had suggested masking the pain with a variety of anti-inflammatory drugs. But when his doctor admitted the adverse side effects, Mike found out the hard way why natural health enthusiasts consider prescription drugs a method of last resort. He started looking for a better answer.

“Let Food Be Thy Medicine”

Hippocrates practiced and taught nearly 2,500 years ago. Often called the “Father of Western Medicine,” much of what he taught resembles what we call a natural or complementary approach to medicine today. He probably wouldn’t even recognize the modern pharmaceutical-driven approach found in many hospitals and doctor offices as medicine.

It turns out Hippocrates was really onto something when he said “let food be thy medicine and medicine be thy food.” We’ve talked about many foods and herbs with healing properties before, such as boswellia, lemongrass, arnica,
lemon balm
, pineapple, turmeric and ginger.

Today I want to tell you about another food you should know about: the purple mangosteen.

The Purple Mangosteen

Mangosteen has been used for thousands of years by traditional healers in folk, ayurvedic, and traditional Chinese medicine in Asia. The indigenous peoples of Southeast Asia used it to remedy a wide range of ailments. They would boil the rind and drink the tea for relief of various digestive issues, infections in the body, inflammation pain, and even malaria-induced fevers. Mashed into a poultice, it was spread over the body to improve numerous skin conditions.

While the fruit’s sweet and tangy, slightly citrus tasting interior pulp gets your attention first, it’s the deep purple yet bitter pericarp (outer rind) of the tangerine-sized fruit that excites scientists and natural health advocates the most. Thanks to its incredibly nutrient and antioxidant-rich pericarp, mangosteen has joined a handful of other superfruits in recent years in gaining widespread notice.

When Mike first heard about mangosteen from a friend a few years ago he decided to give it a try. Since it can be difficult to find fresh mangosteen fruit in the United States, Mike tried a juice supplement made from the whole-fruit mangosteen. He was amazed when years of chronic pain evaporated in 36 hours. Not only that, but he also credits mangosteen juice with stopping his acid reflux and allergies right in their tracks.

The Science Supporting Mangosteen

There’s been a lot of hype about one exotic food or herb after another in the press in recent years. Being skeptical is natural – and healthy. But eating foods rich in antioxidants is backed by solid science. And solid science also backs many of the claims made about the mangosteen. So let’s take a moment to dig into what might make the mangosteen so special.

Mangosteen (Garcinia mangostana) belongs to the scientific family Guttiferae, the same family as St.John’s Wort. What really separates the mangosteen from other natural foods are the amount and variety of a class of phytonutrients called xanthones found in it.

So what are xanthones? Basically, they are a class of plant-derived nutrients with some pretty amazing biological properties… including, some claim, the ability to improve chronic conditions like cancer, diabetes, cardiovascular disease, viral and bacterial infections, allergies, and Crohn’s disease among others.

That’s where the mangosteen really stands out. Its pericarp contains a whopping 43 different xanthones – and some of them have never been found anywhere else.

Among the most studied mangosteen xanthones are alpha-, beta-, and gamma-mangostins, garcinone E, 8-deoxygartanin, and gartanin. Over a dozen studies provide evidence of the anti-inflammatory effects of xanthones on inflammation alone, which is a major source of pain and disease when left unchecked.

These recent studies and many impartial scientific reviews have begun to add serious credibility to what many Southeast Asians have believed for generations… mangosteen is both tasty and a unique healer.

Where to Find Mangosteen

Until recently, mangosteen had only been available in tropical regions of the world where it’s harvested. Only over the past decade has mangosteen been imported and promoted in the United States in a widespread fashion.

Whole fruit mangosteen can still be difficult to find in the United States outside of specialty health food or import food markets in larger cities. Canned fruit can be found online and in some stores.

More commonly available are mangosteen juice, capsules, and powders through many nutritional supplement and health food stores and supermarkets. Of course, they can be found all over the Internet, too.

What I Recommend

While the fruit is great to eat, if you’re looking at the mangosteen for health benefits I recommend you go with a whole-fruit mangosteen juice or juice blend, meaning it includes the pericarp along with the pulp. After all, it’s the pericarp where you’ll find the abundance of phytonutrients like xanthones. And you probably won’t get nearly as many eating the fruit whole because the bitter rind won’t be pleasant for most to eat directly.

If you drink the juice for health, give it time to take effect. While Mike’s story is impressive, some can take as long as three months to notice an improvement. Since whole-fruit mangosteen juice is so potent you can actually benefit from drinking as little as 1 to 3 ounces at each meal.

Since the use of mangosteen is so new in Western nations, I would love to hear your comments below on your experience with this fruit if you’ve taken it for your health. Was it all it’s cracked up to be for you? Let us know!

Related references:

Pedraza-Chaverri J, Cardenas-Rodriguez N, et al. Food and Chemical Toxicology. Medicinal properties of mangosteen (Garcinia mangostana). 2008 Oct;46(10):3227-39.

Berenson L. Science of the Mangosteen and the Role of Inflammation on Chronic Disease. 2008.

Chen LG, Yang LL, Wang CC. Anti-inflammatory activity of mangostins from Garcinia mangostana. Graduate Institute of Biomedical and Biopharmaceutical Sciences, College of Life Sciences, National Chiayi University, 300 University Road, Chiayi 600, Taiwan, ROC. 2008 Feb;46(2):688-93.

Mahabusarakam W, Proudfoot J, Taylor W, Croft K. Study on inhibition of lipoprotein oxidation by prenylatedxanthones derived from mangostin. Chemistry Department, Prince of Songkla University, Hat Yai, Thailand. 2000 Nov; 33(5):643-59.

ScienceDaily. Link Between Inflammation, Cancer Confirmed. 2008 Jun 3.

Nakatani K, Yamakuni T, et al. gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Department of Pharmaceutical Molecular Biology,Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. 2004 Sep; 66(3):667-74.

Bumrungpert A, Kalpravidh RW, et al. Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. The Journal of Nutrition. 2010 Apr;140(4):842-7.

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Is Aspartame the Source of Your Joint Pain?

Monday, July 19th, 2010

Judy, a 55-year old secretary visited her family physician after suddenly developing excruciating joint pain and lower back pain.

Her symptoms, which also included memory loss, severe dizziness and depression, had all appeared within one week’s time.

After undergoing several expensive tests with no answers, her doctor finally asked Judy to keep a food and activity journal to see if it could provide any clues. On a hunch, he asked her to stop drinking a powdered tea mix she had recently purchased to see if that helped. Amazingly, it did.

The pain was completely gone within a week of stopping use of the aspartame-containing product. To confirm the diagnosis, her doctor instructed her to begin adding aspartame back into her diet for a challenge test.

After each of three challenges, says Judy, “my whole body ached from my toes to the neck. I felt as though I had arthritis in my whole body and it hurt to move an arm or even my hand….Since that time, I have not touched anything sweetened with aspartame, and have experienced no unusual aches, joint pain, memory loss or dizziness.”

Judy’s not alone. The artificial sweetener aspartame, consumed by Americans at the rate of about 20 million pounds a year, may well be the cause behind any number of painful and life-altering conditions, including joint
pain
, headaches, severe drowsiness, extreme irritability, depression, and weight gain.

How Much Is Too Much?

It doesn’t take a tremendous amount of aspartame to cause trouble. In fact, just three or four 12-ounce diet drinks per day contain enough aspartame to harm us.

Don’t drink diet soda? You don’t have to. Aspartame is found in over 6,000 processed foods – from powdered drinks, gelatin, tea, coffee, cocoa, juices, frozen desserts, to chewing gums. It’s even in vitamins (including children’s) and medications.

This means the very source of your chronic pain could be in your kitchen cabinet or refrigerator right now.

Sweet Discovery

The introduction of aspartame as a sweetener started after chemist James Schlatter accidentally tasted the new anti-ulcer drug he was developing in 1965, not realizing he had discovered a goldmine. What he discovered was a product 200 times sweeter than sugar.

By the early 70s, aspartame spread quickly to tables in restaurants, diners, and the homes of Americans under the brand names Nutrasweet, Equal, Equal-Measure and Spoonful. Aspartame gained popularity quickly because it didn’t have the aftertaste that its predecessor, saccharine did.

What is Aspartame… exactly?

Aspartame has three components: phenylalanine (50 percent), aspartic acid (40 percent) and methanol, also termed wood alcohol (10 percent). It’s classified as an excitotoxic amino acid. What that means for you is it reacts with specialized receptors in your brain in a way that causes the destruction of certain types of brain cells.

Methanol itself is a poison to your body. The EPA defines a safe consumption limit of it as 7.8 milligrams per day. The problem is a small one-liter bottle of your favorite diet beverage sweetened with aspartame contains about 56 milligrams, or eight times the EPA’s own limit, of this poison!

Remember free radicals?

If you’ve read much about health related issues at all, you’ve likely heard of free radicals. In a nutshell, these are the unstable organic molecules floating around your body which promote aging and the general breakdown of your body.

They’re implicated in many degenerative illnesses including atherosclerosis, cancer, coronary artery disease and arthritis.

Once you realize excitotoxins like aspartame help generate free radicals, not to mention direct effects such as headaches, mental confusion, and balance problems, the long list of aspartame related illnesses and disorders becomes less surprising. Of course, the effects are subtle, cumulative and develop over a prolonged period of time which is why most people don’t immediately suspect aspartame in conditions like:

  • Birth defects
  • Migraines and severe headaches
  • Seizures
  • Insomnia
  • Infections
  • Hives and other allergic reactions
  • Endocrine disorders
  • Specific types of obesity
  • Anxiety
  • Depression
  • Increasing severity and progression of diseases such as Alzheimer’s dementia, Parkinson’s disease, or amyotrophic lateral sclerosis (ALS).

Cancer Risk Higher Than Thought

Independent scientists have long suspected a link between aspartame and cancer. But a few years ago, a massive study conducted at the European Ramazzini Foundation in Italy conclusively documented the direct link.

The study fed groups of rats from 8 weeks old until their natural death a feed mix laced with varying concentrations of aspartame. A significant increase in lymphomas, leukemias and other cancers were found in rats that were fed aspartame, particularly those fed daily doses equal to 20 milligrams per kilogram of body weight. Compare this to the 50-milligram level currently deemed acceptable for humans in the United States. A year later, a second study confirmed the results.

Now what?

The best thing to do is stop using any form of aspartame immediately. While discontinuing use of aspartame can lead to the disappearance of many of the above symptoms, patients who develop full-grown tumors, diabetes, and other more serious diseases cannot usually be cured. Omitting aspartame from one’s diet, however, can sometimes potentially lessen the severity and ongoing degeneration associated with certain disorders. Exercising, improving your nutrition, and adding the appropriate supplements to reduce inflammation will also help. In other words, it’s never too late to start doing the right thing for your body.

Aspartame Alternatives

I really shouldn’t have to spell this out for you, but if you’re using any form of aspartame… stop, right now! Like Judy, you may quickly notice an improvement in pain symptoms. Or you may simply reduce the risk of dying of cancer or suffering from horrible degenerative diseases for the rest of your life. Either way, the change is worth it.

Clearly, adding a ton of sugar back into your diet isn’t great for your health, either. But if you must use sweeteners, honey, maple syrup, and even turbinado sugar (raw sugar) are all healthier alternatives to aspartame.

Another great alternative is stevia, produced from the leaves of a native South American shrub by the same name. The leaves themselves are at least 30 times sweeter than table sugar. Extracts can be ten times sweeter than the raw leaf, yet still have virtually no effect on blood glucose levels.

So, toss the aspartame-containing products you’ve been using and look for those using natural alternatives. Your body will thank you in the long run.

References

Olney JW, et al. Increasing brain tumor rates: is there a link to aspartame? Journal of neuropathology and experimental neurology. 1996 Nov;55(11):1115-23.

Roberts HJ. Aspartame as a cause of allergic reactions, including anaphylaxis. Archives of internal medicine. 1996 May 13;156(9):1027-8.

Soffritti M, et al. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environmental health perspectives. 2006 Mar;114(3):379-85.

Trocho C, et al. Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life sciences. 1998;63(5):337-49.

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How to Reverse Diabetes

Tuesday, June 22nd, 2010

Do you fear for your health or feel exhausted all the time? Are you overweight? Or do you just have too much belly fat?

Do you suffer from diabetes, monitor your blood sugar all the time, have serious blood sugar and insulin imbalances, or have elevated cholesterol, blood pressure, and triglyceride levels? If so, you may find this remarkable story of one my patient’s very interesting.

One evening, after a lecture in New York, a man approached me about becoming my patient. He was rotund, with a round, ruddy face, a booming voice, and a gentle manner. Everything about him was large — his appetite, his belly, and his heart.

Sam was nearly 60 years old, and his love of everything big was waning as he felt the encroachment of death. As we talked, he described years of feeding his fat, drinking a pint of heavy whipping cream every night before bed to keep his weight up.

In the end, the big presence that Sam’s 300-plus pound corpus gave him was not worth the infirmities he suffered. He was diabetic. His insulin was over 200, normal is less than 20. He also had dangerous cholesterol levels, angina, sleep apnea, a sluggish thyroid, and was doggedly fatigued, short of breath at nearly every step, had nasal congestion, swollen legs, dry skin, and yeast grew all over his body.

Sam may sound like a hopeless case, but the truth is that everything Sam had done to his body he did himself and could undo. I told him that if he did everything I suggested he would lose weight, feel better, and all his symptoms would go away. Enthusiastic, though somewhat skeptical, he left my office determined. Three months later when I spoke to him again, he lost 30 pounds, had more energy, his nasal congestion was gone, his
fluid-filled, swollen legs were better, and all of his cravings were gone — he never felt hungry, and he found the program I prescribed
to him easy to follow.

Fourteen months later I saw him again and repeated his blood tests. I was shocked when he weighed in. He had lost 110 pounds without being on a strict deprivation diet. He simply changed his eating and his lifestyle. His diabetes was CURED. His blood sugar dropped from 130 to 74 (greater than 126 fasting denotes diabetes). His HDL and LDL cholesterol and triglycerides were normal without any medication. And he was exercising vigorously three to four times a week.

After a lifetime of uncontrollable appetites, Sam finally found balance and health without suffering. Yes, he changed his diet and lifestyle, but he was able to continue taking pleasure in food. Most importantly, he looked and felt twenty years younger. Now, I know Sam’s story is an extreme one. You may or may not be suffering from problems as severe as those he faced. Even so, I’m sure you can relate to some of what Sam experienced if you are overweight, have high blood pressure, elevated cholesterol, have problems with your blood sugar, or have been diagnosed with type 2 diabetes …

You may feel twenty years older than you are, and, deep down, you may even be terrified by the possibility of additional health complications like heart disease, stroke, dementia, nerve damage, blindness, and amputation or even cancer. Like so many others that suffer with this condition, you just want to live a normal life and get back some of your energy and vitality; you want to turn back the clock and reverse your diabetes …

You can do that. I know most people are skeptical when a doctor tells them they can reverse diabetes, but over the course of this three-part series of blogs I’m going to show you how. You can have the same experience Sam did, and you don’t have to suffer or starve to make that happen.

Later in this blog series, I will tell you how you can do that. Today, I want to explain what I mean by the term “diabesity”. If you have diabetes you have it. But you don’t have to have diabetes or even have symptoms to be suffering from diabesity. In fact most people who have it don’t know they are suffering from a deadly condition that is 100% reversible.

**************IMPORTANT ANNOUNCEMENT*************

I’ve received so many questions about diabesity that I’ve decided to hold a special webinar during which you’ll discover the 7 keys to overcoming diabesity and reclaiming a normal life. My tech team tells me that only 500 viewers can watch at once, so if it’s something that interests you — whether you are overweight, have been diagnosed with diabetes, or are worried about developing it — you may want to reserve your spot now before all of the spots are filled.

****************************************************

Many Names, One Disease — Defining Diabesity You may be one among millions of people who are suffering from a health problem that is now epidemic in our country. Your doctor might have diagnosed you with one of many seemingly different diseases. He may have said you have:

    Insulin resistance

    Pre-diabetes

    Metabolic syndrome

    Obesity

    Syndrome X

    Adult onset diabetes

    Type 2 diabetes

What he likely didn’t tell you is that ALL of these conditions are basically the same thing — just with varying degrees of severity. The underlying causes of ALL of these conditions are the same. And because they are all the same condition, the treatment for all of them is also the same.

That is why I have set aside these conventional diagnoses in place of a new name that more accurately defines the health problems you may suffer from. That term is diabesity.(i) Diabesity is the condition of metabolic imbalance and disease that ranges all the way from mild blood sugar imbalance to full blow diabetes.

Whether you are suffering from a little extra weight around the middle or you have been diagnosed with insulin resistance or even type 2 diabetes, the fundamental underlying biological causes of ALL of these conditions are the same. This is what I’ve discovered in over 20 years seeing thousands of patients.

Diabesity, in its various forms, affects over 1 billion people worldwide. It is a massive global problem, and our current approach to prevention and treatment is obviously not working because millions more are affected every year in a dramatic increase of a condition that was once very rare.

Diabesity is also the leading cause of most chronic disease in the 21st century.(ii) Those with diabesity are at an increased risk of heart disease (iii), (iv),  stroke, dementia(v), cancer(vi), high blood pressure, blindness, and kidney failure. Nervous system damage also affects 60 to 70 percent of people with diabetes and can lead to a loss of sensation in the hands and feet, slow digestion of food in the stomach, carpal tunnel syndrome, sexual dysfunction, and other nerve problems.

So this is VERY real and VERY serious for those who suffer from the condition. Given all of this, one would think the questions on everyone’s mind would be: Why is this happening? What has caused this diabesity epidemic? Why are our current approaches to treating the problem failing so miserably? And what new approaches could we take that would more effectively treat the problem? Few in medicine today are asking these questions, yet their answers are disarmingly simple.

The Problems with Diabesity Treatment — Symptoms, Not Causes

The reason our current approach to treating diabesity fails is because it focuses on treating the symptoms or risk factors of the disease rather than the causes. All of our attention is on treatments that:

    • Lower blood sugar (diabetes drugs and insulin)
    •  Lower high blood pressure (anti-hypertensive drugs)
    •  Lower cholesterol (statins)
    • Thin the blood (aspirin)

But we never ever ask the most important question: Why is your blood sugar, blood pressure, or blood cholesterol too high and why is your blood too sticky and likely to clot? Put another way: What are the root causes of diabesity?

Answering that question must be the focus of our diagnosis and treatment of this disease if we are going to solve this global epidemic.

In truth, diabetes, elevated blood sugar, blood pressure, and cholesterol are simply downstream symptoms that result from problems with our
diet, lifestyle, and environmental toxins interacting with our unique genetic susceptibilities. These are the real causes of diabesity. Unfortunately, few are taking the time to treat them. Using medication or surgery to treat symptoms like imbalanced blood sugar, high cholesterol, high blood pressure, and the other complications of diabetes is like mopping up the floor while the sink overflows.

In medicine today we have a choice. We can continue to mop up this overflow, or we can deal with the source of the problem and turn off the faucet — that is, treat the root problems that are causing your illness. In this three-part blog series, I am going to show you how to turn off the faucet so you can heal from your diabesity and achieve optimal health.

The real solution for diabesity is a comprehensive diet and lifestyle program. And in this series of three blogs I am going to teach you how you can integrate such an approach into your life to heal from your symptoms. I will show you why conventional treatments typically fail, what you can really do to treat diabesity, and explain how healing the 7 key underlying systems in your body is the real solution to the problem.

By following this system you may see many of your lifelong health symptoms evaporate in a matter of weeks or even days in some cases, and you may — for the first time — achieve vibrant health.

Now I’d like to hear from you …

Do you believe you can be healed from diabesity? Have you tried conventional medical treatments? How have they worked for you? Are you ready to try a radically new approach that may help you heal once and for all?

Let me know your thoughts by posting a comment below.

To your good health,

Mark Hyman, MD

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Healing Herbs: Boswellia

Tuesday, June 22nd, 2010

Healing Herbs: BoswelliaBoswellia is a natural inflammation-fighting gum resin extract derived from the Boswellia serrata tree, common to India. It is also known as “Indian Frankincense.” For centuries, the tree’s fragrant, gummy sap, called “oleoresin”, has been tapped for its medicinal properties. It has proven especially valuable for arthritis and back pain sufferers.

The harvested oleoresin contains a mixture of naturally occurring organic acids. These acids inhibit pain and inflammation causing enzymes. They also limit the synthesis of fatty immune system molecules called leukotrienes which contribute to inflammation.

Effective arthritis pain relief

One six-month study compared the efficacy, safety and tolerability of Boswellia extract with the prescription drug valdecoxib (no longer available in the U.S. market due to health risks). The patients enrolled in the study suffered from osteoarthritis of the knee and received either 10mg of valdecoxib taken once daily or 333mg of Boswellia extract (containing 40% boswellic acids) taken three times daily.

The study found patients who took valdecoxib presented statistically significant improvement after one month, but the relief quickly subsided when the drug was stopped. The Boswellia test subjects did not show statistically significant improvement until the second month. However, the on-going relief of Boswellia extract clearly bested the drug by its longer lasting effects. When the valdecoxib was stopped, the pain returned within a day or two. But those who had been taking boswellia reported continued effects a full month after the test had ended.

The researchers reported in their conclusion that “in terms of safety, efficacy and duration of action, the present study shows that [Boswellia serrata extract] was superior to valdecoxib, except for the slower onset of action.”

Hundreds of other studies on boswellia extract have proven it both safe and effective at treating not only osteoarthritis, but also rheumatoid arthritis.

Safer than NSAIDs

Inflammation is a killer, but so are many of the non-steroidal anti-inflammatory drugs (NSAIDs) used to treat it. Boswellia extract fights inflammation as well as most NSAIDs, but without the stomach irritation or ulceration. In fact, at least one study found boswellia more effective at treating ulcerative colitis than the commonly prescribed sulfasalazine. Boswellia also doesn’t carry the severe risk of heart attack and stroke found with some of the newer NSAIDs.

Even though it has been safely used for centuries, a comprehensive safety study was conducted on boswellia just a few years ago. The study found no significant adverse effects other than minor eye irritation. Other studies noted only rare but minor side effects, such as nausea, skin rash or diarrhea.

Of course it’s always a good idea to speak with your health care provider or pharmacist before taking herbs or dietary supplements, particularly if you are taking any prescriptions.

Related references

Ammon HP. Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases [article in German]. Wien Med Wochenschr 2002;152(15-16):373-378.Safayhi H, Sailer ER, Amnon HPT. 5-lipoxygenase inhibition by acetyl-11-keto-b-boswellic acid. Phytomed 1996;3:71-2.

Safayhi H, Mack T, Saieraj J, et al. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 1992;261:1143-6.

Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent. Agents Actions 1986;18:407-12.

Etzel R. Special extract of Boswellia serrata (H15) in the treatment of rheumatoid arthritis. Phytomed 1996;3:91-4.

Gupta I, Parihar A, Malhotra P, et al. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res 1997;2:37-43.

Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of Osteoarthritis of knee- a randomized, double blind, placebo controlled trial. Phytomedicine 2003;10:3-7.

Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian J Pharmacol 2007;39:27-29.

Ammon HPT, Safayhi H, Mack T, Sabieraj J 1993 Mechanism of anti-inflammatory actions of curcumin and boswellic acids. Journal of Ethnopharmacology. 1993 Mar;38(2-3):113-9.

Singh GB, Bani S, Singh S. Toxicity and safety evaluation of boswellic acids. Phytomed 1996;3(1):87-90.

Singh S, et al. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine. 2008 Jun;15(6-7):408-15.

Valdecoxib (Oral Route). MayoClinic.com. Retrieved 19 Jun 2010.

Tramèr MR, et al. Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use. Pain. 2000 Mar;85(1-2):169-82.

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Sarcoidosis: Pain and Death from Inflammation and Fibrosis

Tuesday, May 25th, 2010

Sarcoidosis: Pain and Death from Inflammation and Fibrosis In 1995, actress Karen Duffy – better known as MTV’s VJ “Duff” – returned home to New York after the Emmy Awards in Los Angeles in excruciating pain.

She later described the initial pain in her head like “a burning, sharp pain that felt like I was being electrocuted.” As bad as the pain felt, it soon grew even worse.

Before long, Karen’s monster headache had transformed into a full-body experience. Most of her body was wracked with pain so severe she would curl into a fetal position and try not to cry – even her tears felt like sulfuric acid sliding down her cheeks. The only parts of her body that didn’t hurt were areas mainly on her left side
left numb and paralyzed from whatever disease she had become afflicted with.

Six months of endless MRIs, spinal taps, and other tests later, her doctors through a process of elimination finally diagnosed her condition: a systemic inflammatory disease called sarcoidosis. In Karen’s case, the disease attacked her central nervous system, leaving her partially paralyzed to this day.

While sarcoidosis may affect virtually any area of the body, it most commonly attacks the lungs and lymph nodes where small nodules of immune cells called granulomas are formed. Sometimes these nodules disappear on their own. Other times they leave behind areas of fibrosis, or internal scar tissue.

In the lungs this scarring can permanently impair breathing through pulmonary fibrosis. Actor Bernie Mac, known for his comedic roles in
numerous television shows and movies, was another high profile individual known to have suffered from sarcoidosis. After being hospitalized in 2008 with pneumonia, his publicist announced his sarcoidosis had been in remission for three years and Bernie was expected to make a full recovery. Sadly, Bernie passed away several days later.

Christmas night 2004, yet another legend passed away. Hall of fame defensive end Reggie White, better known to fans as “The Minister of
Defense,” died in his sleep of a cardiac arrhythmia. Sarcoidosis affecting his heart and lungs was ruled the primary cause of death.

While sarcoidosis is a fairly rare autoimmune disorder, inflammation and fibrosis affects every one of us. Half of all heart attacks are caused by inflammation. Considering the widespread problem, no wonder heart disease remains the number one killer in the United States. But that’s not all. Inflammation is also strongly linked to strokes, arthritis, chronic fatigue, and even Alzheimer’s and
other dementing diseases.

Fortunately, the mechanisms behind controlling systemic inflammation are fairly well understood. It boils down to the level of proteolytic
enzymes
which counter the body’s inflammatory response to injury, sickness, or tissue irritation.

When we’re young, our bodies heal quickly. Around our mid-20s, a precipitous drop in bodily production of proteolytic enzymes lead to
extended recovery periods from injuries. The older we get, the longer it takes to heal.

Proteolytic enzymes do more than fight inflammation. They also clean your blood, help fight off viral and bacterial infections, and break down excess scar-creating fibrin. Taking supplemental systemic enzymes not only helps your body keep inflammation in check, it keeps you
healthier by boosting cardiovascular, respiratory and immune system functions throughout your body.

The inflammation fighting and scar erasing properties of proteolytic enzymes haven’t been clinically studied yet (to my knowledge) for the specific treatment of sarcoidosis, but anecdotal evidence from members of sarcoidosis support groups who have tried them indicates it has helped alleviate even symptoms of this harsh disease.

It’s certainly worth further study for sarcoidosis patients – and worth taking to maintain good health in everyone else over age 25. A
30-day supply of systemic enzymes and other natural anti-inflammatory ingredients is currently being offered free at The Healthy Back Institute’s website for those who would like to try them.

Related references
Carney, K. Former MTV VJ tells of battle with chronic illness. CNN Headline News. 2003, Sep 19.
Duffy, K. Model Patient: My Life As an Incurable Wise-Ass. Harper Paperbacks. 2001.
Mignot, S. Actor And Comedian Bernie Mac Dies At Age 50. CBS 2 Chicago. 2008, Aug 9.
Sun-Times Media Wire. Bernie Mac Expected To Recover, Publicist Says. Chicago Sun-Times. 2008, Aug 3.
FastStats – Heart Disease. Centers for Disease Control and Prevention. 2010, Apr 15.
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