Mother Nature's Answer For
It's called Systemic Enzyme Therapy and it has been
used in numerous countries throughout the world for over 50 years.
The word systemic means whole body and systemic enzymes operate
throughout your body in every system and organ. Enzymes, which are
known as biocatalysts - something that makes something else work or
Enzymes are basically the main line of defense
against inflammation. Enzymes are not anti-inflammatory drugs but
rather reduce inflammation by neutralizing the bio-chemicals of
inflammation to levels where the creation, repair and regeneration of
injured tissues can take place.
Reducing inflammation can have immediate impact on
improved heart health, cancer prevention and recovery, and Alzheimer's
prevention. It also helps speed up recovery from sprains, strains,
fractures, bruises, contusions, surgery -- and arthritis.
Unlike NSAID's which may give only temporary relief and do not fix the
underlying cause of the problem, systemic enzymes work to reduce the
inflammation and promote healing without any side effects.
Here are just a few examples
A study published in the
Journal of Medicine, Science, Sports and Exercise found that
"proteolytic enzymes have therapeutic effects in the treatment of
inflammation and soft tissue injuries."
Another study done by
the Institute of Cancer Research in Vienna found that "a combination of
proteolytic enzymes and herbs were effective in treating rheumatoid
arthritis and reducing TGF-b which is known to be present in the blood
when there is cancer."
And in a study done by Dr. Nicholas Gonzales, which was
published in the medical journal, Nutrition and Cancer, Dr. Gonzales
compared systemic enzyme therapy against a new cancer drug,
Gemcitabine. He found that 5 out of 11 patients treated with systemic
enzymes lived two years or longer and not a single patient of the 129
treated with the drug lived more than 19 months!
So, as you can see, not only is systemic enzyme
therapy safe and effective, but also it's often more effective than the
In Addition To Reducing Inflammation
Pain, Enzymes Also...
Break down scar tissue and fibrosis
Fibrosis is scar tissue that builds up in our bodies and over time
creates some much restriction and strain on our organs that they can no
Well, systemic enzymes eat away that excess build up of
fibrin and scar tissue. Doctors throughout Europe and Asia have been
using them for over 50 years to remove scar tissue from surgical
wounds, kidney fibrosis, pulmonary fibrosis and in numerous other
Cleanse the blood systemic enzymes also clean
the blood of excess fibrin that causes the blood to thicken, which sets
you up for clots, which can cause heart attack or stroke. Enzymes also
help take some of the strain off of the liver by keeping the blood
clean and not allowing it to thicken beyond normal.
WARNING: If you are a hemophiliac or are taking
prescription blood thinners, it's strongly recommended that you consult
with your healthcare professional before considering systemic enzyme
Maintain a healthy immune system
enzymes are adaptogenic and they work to restore the body's balance.
When the immune system is low and we become more susceptible to
infections, the enzymes clean the blood to help fight off infection.
And if the immune system is too ramped up, as with auto-immune
diseases, the enzymes work to tone down the immune system and eat the
antibodies that are attacking the healthy tissue.
Red Blood Cells getting
stuck in and amongst fibrin. This happens when there aren't sufficient
proteolytic enzymes in the blood stream.
Fight and kill viruses
another amazing and powerful effect enzymes have is that they seek out
and kill proteins that have viruses attached to them. Systemic enzymes
have shown to be very effective in treating and preventing viral
Systemic enzymes truly are one of
nature's most powerful natural remedies.
If you suffer from any sort of ache or pain, or if you
just want to get and stay as healthy as possible, I urge you to
consider systemic enzymes. They have been used to safely and
effectively eliminate pain and inflammation from all sorts of
conditions like arthritis, colitis, back pain, sciatica, joint pain,
heart disease, cancer and more.
After years of research
and testing, we have created the most powerful systemic enzyme
formulation in the world. But we didn't stop there, we also added
numerous other herbs, vitamins and nutrients that have been proven to
have anti-inflammatory effects and together, they make one extremely
effective combination called
This powerful inflammation fighting formula includes:
Proteolytic Systemic Enzymes - Research
indicates these enzymes work throughout your entire body to help it
fight inflammation, breakdown scar tissue, cleanse the blood and also
boost cardiovascular, respiratory and immune function.
Bromelain - This special natural compound,
which is extracted from pineapple, contains several proteolytic enzymes
that have been shown to short-circuit multiple pain pathways in the
It has been studied extensively since it's discovery in
1957 and hundreds of studies have shown it to reduce inflammation,
reduce and prevent swelling and remove waste and toxins from the blood.
Turmeric Extract - is taken from the dried root
of the plant and it has been used to treat a wide range of ailments for
thousands of years.
Studies have shown that it reduces inflammation by
blocking both the COX-2 and 5-LOX enzymes which create pain. In
addition, Turmeric's antioxidant powers work to seek out and destroy
free radicals in the body which contribute to pain and swelling.
Papain - contains a wide range of proteolytic
enzymes and works by breaking down proteins. In studies it has been
shown to be effective in the treatment of numerous conditions such as
diabetes, herpes, cancer and digestion issues like bloating and chronic
indigestion. Papain has also been shown to attack tumor cells and boost
the immune system.
Boswellia Extract - One of the most widely used
herbs in Indian medicine, it has been used for centuries by traditional
Indian healers to reduce pain and inflammation. Hundreds of studies
have been done proving it's effectiveness and in addition to being a
powerful and safe, natural anti-inflammatory, Boswellia has also been
shown to support healthy blood circulation.
| Scientifically Proven Relief!
The pain reducing powers of Heal-n-SootheŽ have been proven to be highly effective in numerous clinical studies.
For example, in one study, 77 patients taking
400mg/day of Bromelain experienced significant reduction
in pain and swelling.
A recent study
done at the prestigous Sloan-Kettering Cancer Research Center in New
York found that Turmeric was more safe and precise than asprin in
stopping inflammation by shutting down the COX2 enzyme responsible for
pain. But Turmeric caused none of asprin's typical
randomized, double-blind, placebo controlled study, 30 patients
received 333mg, 3x a day of Boswelia. The group who
received the Boswelia had a significant reduction in pain and swelling
and experienced an increase in joint mobility and flexibility as
compared to the placebo group.
these are just a few of the hundreds of studies that have been done to
prove the effectiveness of these ingredients.
Rutin - Found naturally in a variety of plants
and fruits, this flavanoid has been shown to have a strong
anti-inflammatory effect due to it's powerful anti-oxidant activity.
Mojave Yucca (root) - contains
yuccaols and resveratrol which have been studied to potentially reduce
inflammation. Additionally, yucca may have antioxidant activity. Yucca
may be beneficial for anti-inflammatory support, immune support, as
well as digestive support.
Ginger Extract - Used for over 2,500 years in
Asia, Ginger has been used to treat nausea and to reduce pain and
inflammation. It works by decreasing the amount of prostaglandins,
which are what cause you to feel pain.
Devil's Claw - another time-tested natural pain
reliever, Devil's Claw has been used for hundreds if not thousands of
years in Africa. Numerous studies have proven it's effectiveness in
reducing pain and inflammation. In fact, one study found that Devil's
Claw was as effective in treating arthritis pain as common drug,
L-gluathione - a compound found in nearly all
forms of life, L-gluathione protects the body from oxidative damage by
acting as a buffer.
Vitamin E - This fat-soluble vitamin is an
essential nutrient for humans and is known for it's powerful
anti-oxidant properties. Vitamin E has been shown to be beneficial in
numerous situations and conditions such as controlling high blood
pressure, maintaining healthy and balanced cholesterol levels, boost
immune system function and improving circulatory conditions, skin
health, memory and more.
Citrus Bioflavanoids - aid in the absorption of
vitamins and act as important anti-oxidants. Citrus Bioflavanoids
inhibit collagenase and elastase, the enzymes responsible for the
breakdown of connective tissue. In addition to protecting connective
tissues, they also protect against free radical damage.
On their own, each of these ingredients have been proven
through both clinical studies and thousands of years of use, to be safe
and effective. But together, they work synergistically to quickly
reduce inflammation and pain. And unlike prescription and
over-the-counter NSAID's, Heal-n-SootheŽ works without
the dangerous and harmful side effects.
Heal-n-SootheŽ not only has the most powerful
combination of natural
anti-inflammatory and pain relieving ingredients, but it also has the
strongest and highest potency of any proteolytic enzyme formulation
And, unlike most supplement manufacturers who will call it a
blend" and don't say how much of each is included, we show you exactly
much of each ingredient is in the product.
Not only can you not find a more effective and powerful supplement, but
can't even purchase an enzyme formula like this at your local drug
Try Heal-n-SootheŽ Now For FREE!
Look, I know your skeptical. You should be. Look at all the big drug
companies who are lying to you each and every day trying convince you
their dangerous (sometimes deadly!) drugs are safe.
So I thought there's no better way for you to find out if Heal-n-SootheŽ will work for you, than having you try it. And that's why I'd like to send you a 90 count bottle, a one-month supply for free. You just pay the shipping and handling. This is a real $59 value and as you can imagine, I can't offer this forever so I urge you to grab your free bottle today.
WARNING: Persons who suffer from medical
conditions or who are taking medications should consult their physician
prior to taking this product. This product may thin the blood and may
not be appropriate for all persons. Do not take this product if you
know or suspect that you are allergic to pineapple, papaya, or any
ingredients in this product. As with all dietary supplements, those who
are pregnant or nursing should consult their physician prior to taking
Every week we receive dozens of great stories from people who were finally able to dump their pain meds after taking Heal-n-SootheŽ. But I don't expect you to take my word for it... take a look at these:
Here's What People Are
Here's my story:
had orthopedic problems since I was 7 years old. I figured up that over
the last 31 years (I'm 38 now), I've had a total of 14 surgeries---6 of
them knee surgeries and 1 foot surgery---plus a broken pelvis and
sprained SI joint from a past car accident. After the foot surgery 10
years ago, the doctor decided I would benefit from taking Celebrex. It
helped a good bit, but I haven't been pain-free at any point in that
time. Recently, after being diagnosed with severe arthritis in one knee
and moderate arthritis in my foot, the doctor doubled my dosage of
Celebrex. I couldn't discern any improvement on the new dosage. Also, I
began getting concerned about the possibility of the prolonged usage of
this drug causing liver damage. I have had blood tests every 6 months
to monitor the health of my liver, and so far no damage has been done.
However, it finally hit me that the doctors probably wouldn't take me
off the Celebrex until I got a negative report on my blood
tests---which would mean the damage had already been done!
I decided it was time to at least try life without this medication. I tapered off my dosage, and decided to try your Heal-n-SootheŽ. After a week off the medication, I felt worse than ever as my body was "detoxing" from Celebrex. Another week later, after several days on Heal-n-SootheŽ, I felt a little better. I have now been taking Heal-n-SootheŽ for 30 days, and I feel the same as I did while taking the double dosage of Celebrex. I have hope that after more time on Heal-n-SootheŽ, I will feel even better---and I like that right now I'm getting at least the same, if not yet better, anti-inflammatory effect from natural enzymes, rather than from a chemical that could potentially harm my liver.
Thanks so much!
stay-at-home Wife & Mom to 4 kids
"I can't imagine life without Heal-n-SootheŽ!"
"I really think the Heal-n-SootheŽ have been doing a great job on me! I have just started my 2nd month of using them and for right now I can't imagine life without them! I do feel better.
Thanks for a great product."
"This stuff ROCKS! I felt improvement the first day!
eliminates aches and pains!"
"As a serious student of martial arts, my body has taken a beating and no matter how good you are about taking care of yourself, we all have aches and pains. Well, I have NEVER experienced anything that works as well as Heal-n-SootheŽ... this stuff rocks!
I felt improvement the very first day and not only does it eliminate
aches and pains, but my flexibility has also increased quite a bit. Now
I take it after every hard training session to make sure I don't wake
up sore, stiff and achy the next morning. If you have any aches and
pains I suggest you give this stuff a shot!"
Chief Krav Maga Instructor and One of Only 30 Krav Maga Black Belts in
"WOW! Huge difference
I stopped taking painkillers!"
"All I can say is a big WOW and thank you. I have only
been taking them for 4 or 5 days, but have noticed an huge
difference. I stopped taking my strong painkillers, Co
Codemal (the strongest) and Dihydrocodine, which I was taking every day
and the full limit allowed in a day.I feel "almost" normal
From a very very grateful,
"Thank You for all the Emails you have been sending me since I enrolled
in the "Lose The Back Pain System"
I also purchased the Heal-n-SootheŽ Capsules at the very Welcome Price!
I stopped taking all NSAIDS Immediately (which I have been taking for five years) and started taking the Heal-n-SootheŽ Capsules - To my delight about half the burning sensations in the front and sides of my shins disappeared by the second day of use.
The awful debilitating Cramps in my Calves and Feet ceased almost altogether - Leaving me now to contend with ' Only ' Sciatica in my right buttock and leg - numbness in both my feet and toes and pains in the soles of my feet and heels, like standing on Golf Balls - which in itself is a Great improvement - So I will continue with a further course of the Heal-n-SootheŽ Capsules :-)
We have enjoyed Every
moment of the Video and Audio and the Emails and also the Further Links
- Our heads are Spinning - with glee at the prospect of Help may yet be
at hand !!
Best Wishes to You All
Chris and John
"My pain and inflammation went down in just 2-days!"
"I have been taking Heal-n-SootheŽ, for 3 weeks now. I must say at first I was very skeptical, I was thinking "How can this really help if my medication the doctor gave me does not work??!" But sometimes you reach a point or a day where the pain is so bad, that you will try anything, any price, just anything that might have a slight chance of getting rid of your pain...So I did.
And I was
pleasantly surprised, after about 2-3 days on the activation dose, I
noticed reduced inflammation, and my pain in my leg reduced. At first I
was thinking "Maybe its just the nice weather we have here in the U.K
at the moment?" : )
I realized that it must be the Heal-n-SootheŽ, because I missed one days dosage and the next day I felt really bad : ( It took 2 days after to get things back on track, and I make sure I do not forget them now. It means that I am able to stretch further and more often as the other post stated, and walk more. I'm a believer that you "Can't put a price on your health"."
Dan Monahan, England
"I can walk to the store again without pain!"
I tried the Heal-n-SootheŽ free bottle that I received. You were right! It worked really good and I do feel much better. My back pain is much improved and since taking the Heal-n-SootheŽ I can walk the 2 blocks to the grocery store, spend an hour gathering groceries, then walk back home with my cart of groceries. I don't even have to sit down or lie down when I get home and my back is not hurting. Not only that, but I seem to have more energy and generally feel better. Heal-n-SootheŽ is great!
I really believe that if I continue with the Lose the Back Pain exercises and keep working on my weight problem, I will soon not have to rely on pills of any kind. I am so glad I found and purchased your Lose the Back Pain System and Heal-n-SootheŽ. It has exceeded my expectations. I am improving rather slowly, but I AM STEADILY IMPROVING, thanks to you guys and the rest of your group.
San Diego California area
"Thank you!!! Heal-n-SootheŽ gave me a new PAIN FREE life!"
Just a note to tell you how much your Heal-n-SootheŽ has helped me in just a week. It is working very well. I have a crooked spine, and sciatic nerve problems. Your product has given me a whole new life of PAIN FREE. I can actually golf now. Please keep sending every month. It has made a big difference in my life. Thank You... Thank you !!!!!
Sandra Marginet, Michigan
"My back-pain subsided to almost nothing I don't have
to 'play through the pain' anymore! Thank you so much!"
Recurring back pain from previous soccer seasons affected me again in August when I began my Fall soccer season. At first I was playing through the pain and then I started taking Heal-n-SootheŽ. Within the first week I noticed a significant decrease in the amount of pain I felt.
I have been taking them now for nearly two months and over the course of these two months my back pain has subsided to almost nothing and I have been able to continue playing soccer all season. I truly believe that Heal-n-SootheŽ has enabled me to get to where I am today which is playing pain-free.
Thanks, That is my story and thank you so much for your help!"
"WOW! What a difference!"
"Hi Steve, I just wanted to tell you guys at the HealthyBack Institute what a geat product you have in this Heal-n-SootheŽ. I have been taking it for about 4 months now and all I can say is, WOW, what a difference! I wish I had known about Enzyme therapy sooner. I noticed a difference right away and now when I hit it hard on the tennis court or in any other activity I increase the dosage for a few days after and my recovery is almost instant. All I can say is thank you for the help and support and send me some more!"
"An amazing 'serendipitous' benefit ..."
"Thank you so much for the advice. I just wanted to tell you about an amazing, "serendipitous" benefit I've gained from taking Heal-n-SootheŽ. While they truly help my back pain when I double the recommended dose, I've found that they've practically "cured" an ongoing, life long, severe digestive problem.
I was at the point where I couldn't even drink water without serious pain, bloating and gas. My reflux was so bad that I had to sleep sitting up. While I do take other digestive enzymes and they help somewhat, they have not controlled the problem sufficiently. Recently, it has gotten so bad that I've been forced to go through the usual battery of costly and intrusive tests...only to find once again...NOTHING. Then, one day about a week ago, I decided to double my Heal-n-SootheŽ dosage because of increased back pain.
About 3 days later, I noticed that my digestive problems were ALL so much improved that I practically forgot about them. I can only attribute the improvement to the Heal-n-SootheŽ because I have not taken any other supplements.
Thank you, thank you, thank you"
"I'm off prescription Celebrex because of Heal-n-SootheŽ.
My heartfelt thanks!"
"YOU GET IT" was a comment I recently received from Steve Heffron, after placing a call to inquire about questions I had regarding "Heal-n-SootheŽ" and "Lose The Back Pain". Steve spent considerable time with me answering my questions and offering suggestions.
I "get it" because of the considerable research you put into both the
enzymes and the muscle imbalance issue. Once I reviewed the books and
DVD's, did my assessment and began the stretches, it occurred to me
that this is the most common sense approach to healing my body. Why do
so many of the professionals not "get it"?
I had convinced myself that taking Celebrex may cause side effects which could endanger my life, but was willing to take the risk for the sake of "quality of life". I am happy to report I no longer take Celebrex, once the only drug that would allow me to function "normally" by blocking the pain. The Heal-n-SootheŽ reduces the inflammation to a point where I can now look forward to a productive day, plan trips and live with about 80% less pain. I am currently working on the other 20% as I gradually, at my own pace, address the muscle imbalances and do the stretches as recommended in the Lose the Back Pain System.
I now apply what I have learnt about muscles imbalances on a daily
basis to avoid triggering spasms.
It took me 4 and half years of trial and error before I found your website. Another 2 months of procrastination, scepticism, and reading your articles and newsletters before I finally decided to order the Lose The Back Pain System and the Heal-n-SootheŽ. So glad I did, wish I had done it sooner!
Heartfelt thanks Jesse and Steve. I hope you continue to help others as
you have helped me.
P.S. Love the new
"As a pharmacist I've seen it all. Heal-n-SootheŽ is as effective as prescription anti-inflammatories, but MUCH SAFER."
"As a pharmacist with a keen interest in natural supplements I can safely say I've seen it all. But for patients with pain - who are looking for an answer outside of dangerous prescription medications - I have only a handful of recommendations. Heal-n-SootheŽ is on that short list.
It's not only as effective as prescription anti-inflammatories, but is much safer. And, unlike other supplements on the market, Heal-n-SootheŽ really is free of any fillers or colorants. It truly is all natural.
The point is this: if you're sitting on the fence about other options to treat your pain you owe it to yourself to give Heal-n-SootheŽ a fair shot. You'll be happy you did."
Dr. Curtis Alexander, Registered Pharmacist
Doctor of Pharmacy
No More PMS Pain
"I was stuck in a 3 day meeting out of town and started my period unexpectedly. There I was miles from home with no easy way to get my usual pain relief medicine. I quietly asked around and a friend gave me some of her Heal-n-SootheŽ. "Something is better than nothing I thought" But boy was I wrong... This something was FANTASTIC. Usually it hurts so much I find myself totally distracted or I'm at least very uncomfortable the whole 5 days even with traditional over the counter pain relief supposedly designed for that unpleasant week every month. But with this I felt great... no pain and I can't believe how fast it worked! I now have two bottles on stand by... one for the office and one for the house."
Christa Trantham, Dallas Texas
Heal-n-SootheŽ Frequently Asked Questions
Q: How often should Heal-n-SootheŽ be taken?
A: Heal-n-SootheŽ should be taken at least once per day and can be taken as often as three times per day on empty stomach: 30 minutes before or 60 minutes after meals for best results. Some people find that a single dose before bed works best.
Begin by taking 2 capsules twice per day or 4 capsules once per day. If
you do not feel a reduction in pain at that dosage, experiment with a
higher dosage by gradually increasing the dosage by 1-2 capsules per
day until you find what works best for you. *
Q: Are there any Side Effects?
A: Proteolytic enzymes have
an excellent safety record, with no significant side effects reported.
With any supplement, however, there is always the risk of developing an
allergy to one or more ingredients. If this happens, you should
discontinue use. *
Q: Is Heal-n-SootheŽ made with any animal product?
A: NO, Heal-n-SootheŽ is 100% natural and contains NO animal derivatives. *
Q: Can I take Heal-n-SootheŽ with other medications?
A: Individuals taking any medication should consult physician prior to taking Heal-n-SootheŽ, it is recommended that you wait at least 60 minutes after taking Heal-n-SootheŽ before taking any medications. *
Q: Who should not take Heal-n-SootheŽ?
A: Persons who suffer from
medical conditions or who are taking medications should consult their
physician prior to taking this product. This product may thin the blood
and may not be appropriate for all persons. Do not take this product if
you know or suspect that you are allergic to pineapple, papaya, or any
ingredients in this product or suspect that you have an ulcer. As with
all dietary supplements, those who are pregnant or nursing should
consult their physician prior to taking this product.*
- Individuals taking prescription blood thinners (Coumadin, Heparin,
- Anyone who will be having surgery in less than two
- Individuals with known ulcers of the stomach
- Pregnant or lactating women
- Individuals currently taking
- Individuals with an allergic reaction to
pineapples or papayas
- Individuals under the age of 13
Q: How long should I take Heal-n-SootheŽ?
A: Heal-n-SootheŽ can and should be taken daily along with your multi-Vitamin for as long as you want to keep inflammation in check and continued support for soft tissue recovery, improved joint function and maintaining a healthy immune response as well as support to cardiovascular and respiratory function. *
Q: Warning about Side Benefits?
A: It is possible that you
may experience the following effects on the body.
- For individuals with sinus issues, you may experience some
drainage for a short time as the mucus thins and is eliminated from the
- For individuals with digestive issues, you may
experience some gas or loosing of your stool as undigested matter is
broken down and eliminated. *
- For individuals with
borderline high blood pressure, as fibrin is eliminated from the body,
there will be less resistance on the blood and thus your blood pressure
could come down. *
- For women with Uterine Fibroids, you may
experience some vaginal discharge as the Fibroid is broken down and is
Clinical Studies Used In The Research and Development of Heal-n-SootheŽ
G. Klein and W. Kullich, "Reducing Pain by Oral Enzyme Therapy in
Rheumatic Diseases," Wien Med Wochenschr 149 (1999): 577-80.
Stone MB, Merrick MA, Ingersoll CD, Edwards JE. Preliminary comparison
of bromelain and Ibuprofen for delayed onset muscle soreness
management. Clin J Sport Med. 2002 Nov;12(6):373-8.
J. C. Dekkers, L. J. van Doornen, and H. C. Kemper. "The Role of
Antioxidant Vitamins and Enzymes in Prevention of Exercise-Induced
Muscle Damage, " Sports Med 21, no. 3 (March 1996): 213-38.
Inderst, R.: Systemic enzyme therapy. Journal of Pharmacy 52 (1992).
Ekerot, L. K; Ohlsson, K.; Necking, L.: Elimination of
protease-inhibitor complexes from the arthritic joint. In. J. Tissue
Reac. VII: 391 (1985).
Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T, Hokamaki J,
Yoshimura M, Nakamura H, Yodoi J, Ogawa H. Vitamin E improves
fibrinolytic activity in patients with coronary spastic angina. Thromb
Bounous G, Molson J.
Competition for glutathione precursors between the immune system and
the skeletal muscle: pathogenesis of chronic fatigue syndrome. Med
Hypothesis 53;(4): 347-349
Sen CK. Nutritional biochemistry of cellular
glutathione. Nutr Biochem 1997;8:660-72.
Johnston CS, Meyer CG, Srilakshmi JC. Vitamin C elevates
red blood cell glutathione in healthy adults. Am J Clin Nutr
Lenzi A, Culasso F, Gandini L, et al.
Placebo-controlled, double-blind, cross-over trial of glutathione
therapy in male infertility. Hum Reprod 1993;8:1657-62.
Lands LC, Grey VL and Smountas AA. Effect of a cysteine
donor on muscular performance.J Appl Physiol. 87 (4):1381-1385 1999.
Powers SK, JI LL, Leeuwenburgh C. Exercise
training-induced alterations in skeletal muscle antioxidant capacity:a
brief review. Med. Sci. Sports Exerc. Vol31#7:987-997 1999.
Sen CK. Glutathione homeostasis in response to exercise
training and nutritional supplements. Molecular & Cellular
Biochemistry. 196:31-42 1999
Julius M, Lang C, Gleiberman L, et al. Glutathione and
morbidity in a community-based sample of elderly. J Clin Epidemiol
Hagen TM, Wierzbicka GT, Sillau AH, et al. Fate of
dietary glutathione: disposition in the gastrointestinal tract. Am J
Favilli F, Marraccini P, Iantomasis T, Vincenzini MT.
Effect of orally administered glutathione on glutathione levels in some
organs of rats: role of specific transporters. Br J Nutr
Witschi A, Reddy S, Stofer B, Lauterburg BH. The
systemic availability of oral glutathione. Eur J Clin Pharmacol
Hunjan MK, Evered DF. Absorption of glutathione from the
gastro-intestinal tract. Biochim Biophys Acta 1985;815:184-8.
Emele, J. F.; Shanaman, J.; Winbury, M. M.: The
analgesic-anti-inflammatory activity of papain. Arch. Int. Pharmacyn.
Ther. 159: 126 (1996).
Kameke, E. v.: Inflammation and its treatment with
hydrolytic enzymes and rutin. Forum of the General Practitioner (Forum
des Praktischen- und Allgemeinarztes) 9 (1981).
Amborse, A. M.; De Eds, F.: Effects of rutin on
permeability of cutaneous capillaries. Pharmacol. Esp. Ther. 90: 359
Ambrus, J. L. et al.: Absorption of exogenous and
endogenous proteolytic enzymes. Clin. Pharmacol. Ther. 8: 362 (1967).
Bartsch, W.: Treatment of zoster with proteolytic
enzymes. The Informed Physician 2: 424 - 429 (l974).
Baumhackl, U.; Fordermair, S.: Enzyme therapy in
multiple sclerosis. A preliminary report on a multicenter study.
General Medicine (Allgemeinmedizin) 19 (4): 169 - 172 (1990).
Baumuller, M.: XXIV FMS World Congress of Sport
Medicine. Symposium on Enzyme Therapy in Sports Injuries. May 29, 1990,
p 9. Elsevier Science Publisher, Amsterdam (1990).
Blonstein, J. L.: Oral enzyme tablets in the treatment
of boxing injuries. Practitioner 198: 547 (1967).
Dittmar; F. W.: Enzyme therapy in inflammatory pelvic
disease. The Medical World (Die Medizinische Welt) 37: 562 - 565
Dunkel, R: Therapy investigations with proteolytic
enzymes in camel pox. Veterinary Review (Tieraztliche Umschau) 11:580
Goebel, K. M.: Enzyme therapy in ankylosing spondylitis.
In: Medical Enzyme Research Society. Systemic Enzyme Therapy, 17th
meeting. Vienna (1991).
Goldberg, D. M.: Enzymes as agents for the treatment of
disease. Clin. Chimi. Acta 206: 45 - 76 (1992).
Hiss, W. F.: Enzymes in sport medicine and traumatology.
Journal for Natural Therapy Methods (Zeitschrift fur Naturheilmethoden)
Volume 2: 1 (1979).
Isaaksson, J. I.; Ihse, I.: Pain reduction by oral
pancreatic enzyme preparation in chronic pancreatitis. Dig. Dis. Sci.
28: 97 - 102 (1983).
Klein, G.; Pollmann, G.; Kullich, W.: Clinical
experience with enzyme therapy in patients with rheumatoid arthritis in
comparison with gold. General Medicine (Allgemeinmedizin 19 (4): 144 -
Klein, G.; Schwann, H.; Kullich, W.: Enzyme therapy in
chronic polyarthritis. Natural and hollistic Medicine (Natur- und
Ganzheitsmedizin) 1: 112 - 116 (1988).
Kleine, M.-W.; Volger, W.: Systemic enzyme therapy.
Introduction and overview. General Medicine (Allgemeinmedizin) 19 (4):
119 - 124 (1990).
Kleine, M.-W.; Pabst, H.: Action of an oral enzyme
therapy in experimentally induced hematomas. Forum of the General
Practitioner (Forum des Praktischen- und Allgemeinarztes) 27: 42
Kleine, M.-W.: Treatment of herpes zoster with
proteolytic enzymes. Therapy Week (Therapiewoche) 37: 1108 - 1112
Laffaioli, R. V. et al: Prognostic significance of
circulating immune complexes in a long-term follow up of breast cancer
patients. Oncology 45: 337 - 343 (1988).
Mahr, H.: Enzyme treatment of inflammatory venous
diseases, of deep vein thrombosis and of post-thrombotic syndrome.
Experience Therapy (Erfahrungsheilkunde) 32: 117 - 121 (1983).
Matthews, D. M. Protein absorption - then and now.
Gastroenterology 73: 1267 - 1279 (1977).
Matthews, D. M.: Protein absorption. Wiley-Liss, New
Netti, C; Bandi, G. L.; Pecile, A.: Anti-inflammatory
action of proteolytic enzymes of animal, vegetable or bacterial origin
administered orally compared with that of known antiphlogistic
compounds. II Farmaco Ed. Pr. 27: 453 (1972).
Neuhofer, C. H. et al: Pathogenic immune complexes in
multiple sclerosis. Their elimination by hydrolytic enzymes - a
therapeutic approach. International Multiple Sclerosis Conference,
Rome, Sept 14 - 17, Monduzzi Editore S. p. A., Bologna (1988)
Neuhofer, Ch.: Enzyme therapy in multiple sclerosis.
Hufeland Journal 2: 47 - 50 (1986).
Rosner, L. J.; Ross, S.: Multiple Sclerosis: New hope
and practical advice for people with MS and their families. Prentice
Hall Press, New York (1987).
Scheel, W.; Pischnamazadeh, M.: Proteolytic enzymes as a
simple and safe method for the prevention of lymphedema after
mastectomy. Med. World (Med. Welt) 35: 1032 - 1033 (1984).
Seifert, J. et al.: Quantitative analysis about the
absorption of trypsin, chymotrypsin, amylase, papain and pancreatin in
the G.I. tract after oral administration. General Physician
(Allgemeinarzt) 19 (4): 132 - 137 (1990).
Seifert, J.; Ganser, R.; Brendel, W.: Absorption of
proteolytic enzymes of plant origin from the GI tract into the blood
and lymph of adult rats. German Journal of Gastroenterology (Z.
Gastroenterol.) 71: 1 (1979).
Stauder, G.; Streichhan, P.; Steffen, C.: Enzyme therapy
- a complete description. Natural and Hollistic medicine (Natur- und
Ganzheitsmedizin) 1: 68 - 89 (1988).
Stauder, G. et al.: Adjuvant therapy of HIV infections
with hydrolytic enzymes: Course of neopterin, CD4 T-cells, immune
complexes (IC), and clinical efficacy. 8th International Workshop of
Biochemical and Clinical Aspects of Peridines. St. Christoph (Tyrol),
Febr. 11 - 18 (1989).
TW Magazin: Systemic enzyme therapy - Present status and
advances. Therapy Week (Therapiewoche) 37 (1987)
Wolf, M.; Ransberger, K: Enzyme therapy.
Maudrich-Verlag, Vienna 1970.
Wrba, H.: Treatment of cancer with proteolytic enzymes.
In: Wrba H. (editor): Combined Tumor Therapy pp 131 - 145,
Hippokrates-Verlag, Stuttgart 1990.
Aftab J. Ahmed and Edmund A. Byrke, "Difference between
Systemic Enzymes and Digestive Enzymes"; "Role of Ribose in Stimulating
Natural Energy Production"; "Importance of methyl-sulfonyl-methane."
D. V. Graham, "Enzyme Replacement Therapy of Exocrine
Pancreatic Insufficiency in Man," N Engle J Med 296
Robert Michael Kaplan, "Losing Weight Wisely, "Alive:
Canadian Journal of Health & Nutrition, March 1992, no. 117:
R. Fiasse et al., "Circulating Immune Complexes and
Disease Activity in Crohn's Disease, Gut 19 (1978): 611-17.
M. Wolf, "Der Einfluss von Proteasen auf
Venenentzundungen," in M. Wolf and K. Ransberger, Enzymthempie
K. Nouza, "Outlooks of Systemic Enzyme Therapy in
Rheumatoid Arthritis and Other Immunopatholgical Diseases," Acta
Univ Carol (Med) (Praha) 40 (1994): 101-4.
W. F. Hiss, "Enzymes in Sports Medicine and
Traumatology," Journal for Natural Therapy Methods (Zeitschrift fur
Naturheilmethoden) 2 (1979): 1.
S. Worschhauser, "Conservative Therapy in Sports
Injuries. Enzyme Preparations for Treatment and Prophylaxis," General
Medicine (Allgemeinmedizin) 19, no. 4 (1990): 173.
The Associated Press, "Report: Celebrex Linked to 10
Deaths," April 20, 1999. See also D. R. Lichtenstein and M. M. Wolfe,
"COX-2-Selective NSAIDS," JAMA 284, no. 10 (2000): 1297-99.
H. Wrba. "Systemic Enzyme Therapy: Newest Status and
Progress," Therapie Woche 37, no. 7 (1987).
J. Anderson and J. Stine, "Detoxing from Toxins," in T.
Nichols and N. Faas, eds. Optimal Digestion (New York: Harper
Shoskes D, Lapierre C, Cruz-Correa M, Muruve N, Rosario
R, Fromkin B, Braun M, Beneficial effects of the bioflavonoids curcumin
and quercetin on early function in cadaveric renal transplantation: a
randomized placebo controlled trial. 2005 Dec 15;80(11):1556-9.
Niederau C, Gopfert E. The effect of chelidonium-
and turmeric root extract on upper abdominal pain due to functional
disorders of the biliary system. Results from a placebo-controlled
double-blind study Med Klin (Munich). 1999 Aug 15;94(8):425-30. German.
Petruzzellis V, Troccoli T, Candiani C, Guarisco R,
Lospalluti M, Belcaro G, Dugall M.
Oxerutins (Venoruton): efficacy in chronic venous
insufficiency--a double-blind, randomized, controlled study. Angiology.
Cesarone MR, Incandela L, DeSanctis MT, Belcaro G,
Griffin M, Ippolito E, Acerbi G. Treatment of edema and increased
capillary filtration in venous hypertension with HR (Paroven,
Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective,
placebo-controlled, randomized, dose-ranging trial. J Cardiovasc
Pharmacol Ther. 2002 Jan;7 Suppl 1:S21-4.
Cataldi A, Gasbarro V, Viaggi R, Soverini R, Gresta E,
Mascoli F. Effectiveness of the combination of alpha tocopherol, rutin,
melilotus, and centella asiatica in the treatment of patients with
chronic venous insufficiency. Minerva Cardioangiol. 2001
Ortolani O, Conti A, De Gaudio AR, Masoni M, Novelli G.
Protective effects of N-acetylcysteine and rutin on the lipid
peroxidation of the lung epithelium during the adult respiratory
distress syndrome. Shock. 2000 Jan;13(1):14-8.
Noroozi M, Angerson WJ, Lean ME. Effects of
flavonoids and vitamin C on oxidative DNA damage to human lymphocytes.
Am J Clin Nutr. 1998 Jun;67(6):1210-8.
Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and
tolerance of an oral enzyme combination in painful osteoarthritis of
the hip. A double-blind, randomised study comparing oral enzymes with
non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006
Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess
W. Efficacy and tolerability of oral enzyme therapy as compared
to diclofenac in active osteoarthrosis of knee joint: an open
randomized controlled clinical trial. J Assoc Physicians India. 2001
Itoh H,Ohkuwa T,Yamazaki Y,Shimoda T,Wakayama A, Tamura S, Yamamoto Vitamin E
supplementation attenuates leakage of enzymes following 6 successive
days of running training.Int J Sports Med 2000
Wu D, Han SN, Meydani M, Meydani SN. Effect of
concomitant consumption of fish oil and vitamin E on production of
inflammatory cytokines in healthy elderly humans. Ann N Y Acad Sci.
Block G, Jensen C, Dietrich M, Norkus EP, Hudes M,
Packer L. Plasma C-reactive protein concentrations in active and
passive smokers: influence of antioxidant supplementation. J Am Coll
Nutr. 2004 Apr;23(2):141-7.